你将学到什么
Collect, access, and download whole bacterial genomes from public repositories
Investigate and navigate bacterial genomes and their annotation using Artemis
Identify genomic regions with low/high GC (guanine-cytosine) content, often associated with virulence
Perform simple comparative analyses between bacterial genomes
课程概况
Applying increasingly powerful computation to genomics contributes to important medical breakthroughs.
On this course, you will discover the basic principles of microbial bioinformatics analysis, and comparative genomics. Using Artemis, a free genome browser, you will find out how to investigate whole bacterial genomes, and through the analysis of bacterial genes and proteins, you will explore the genomic features of pathogens.
By the end of this course, you will be able to use genomic data to increase your knowledge of microbial genomes.
课程大纲
Multi-FASTA files
Reference and draft bacterial genomes
Introduction to Artemis, an open source genome browser
面向人群
This course would benefit those interested in learning how to use tools to investigate bacterial genomes, and acquire bioinformatics skills to evaluate the role of microbial genes in disease. Using analytical tools to access and probe genomes, learners will find out how to perform comparative analyses of genes and their protein products.
The course will be of interest to undergraduates, post-graduates, researchers, bioinformaticians, microbiologists, and healthcare professionals. The opportunity to use online computational tools to probe bacterial genomes will also be of interest to teachers and their 16-18-year-old science and computing students.
Bacterial Genomes: From DNA to Protein Function using Bioinformatics is a recommended pre-requisite. Scientific terminology is explained.
